一、基本情况
任深圳,男,博士研究生,讲师,元光学者,硕士生导师。
教育背景:
2015-2020,南京大学,生命科学学院,生物学,博士;
2011-2015,江苏大学,药学院,药学,本科;
工作履历:
2020-至今:河北工业大学,讲师、硕导
学术兼职:
中国化学会会员
中国生物物理学会会员
International Journal of Biological Macromolecules等杂志审稿人
二、硕导所属(含跨转)学科、专业学位类别
1、生物学学科
研究方向一:基于功能性多酚化合物构建金属-多酚纳米网络(MPN),用于肿瘤可视化治疗及免疫调节;
研究方向二:靶向小分子抑制剂的设计、合成、结构优化及生物活性评价。
2、生物医学工程
研究方向一:基于金属-有机骨架(MOFs)构建多功能纳米载体,用于肿瘤多模态成像、多物理场治疗和免疫调节等;
研究方向二:离子通道调节剂的筛选、结构改造和生物活性评价。
三、主持、参与的科研及教研项目情况(含获奖情况)
1)河北省自然科学基金,青年项目,2022.1-2024.12,主持;
2)河北省教育厅,重点项目,2021-2023,主持;
3)国家自然科学基金,面上项目,2019-2022,67.5万元,参与;
4)国家自然科学基金,面上项目,2017-2020,60万元,参与。
奖励与荣誉:
河北工业大学“元光学者”
四、近年来发表代表性论文情况(仅限第一作者或通讯作者),主编或参编的教材、专著情况,获得专利情况等
代表论文(*为通讯作者,#为共同第一作者):
[1]Xiao Yang; Ning Zhang; Gen Li; Mingzhe Zhang; Chunli Pang; Shenzhen Ren*; Hailong An; Polyphenol-mediated biomimetic MOFs hybrid nanoplatform for catalytic cascades-enhanced cancer targeted combination therapy, Materials & Design, 2022, 223: 111217
[2] Dan Zhu; Bin Wang; Xiao-Hua Zhu; Hai-Liang Zhu*; Shen-Zhen Ren*, A MnO2-coated multivariate porphyrinic metal-organic framework for oxygen self-sufficient chemo-photodynamic synergistic therapy, Nanomedicine: Nanotechnology, Biology and Medicine, 2021, 37: 102440.
[3] Shen-Zhen Ren; Xiao-Hua Zhu; Bin Wang; Ming Liu; Shu-Kai Li; Yu-Shun Yang*; Hailong An*; Hai-Liang Zhu*, A versatile nanoplatform based on multivariate porphyrinic metal-organic frameworks for catalytic cascade-enhanced photodynamic therapy, Journal of Materials Chemistry B, 2021, 9: 4678-4689.
[4] Shen-Zhen Ren; Bin Wang; Xiao-Hua Zhu; Dan Zhu; Ming Liu; Shu-Kai Li; Yu-Shun Yang*; Zhong-Chang Wang*; Hai-Liang Zhu*, Oxygen self-sufficient core-shell metal-organic framework-based smart nanoplatform for enhanced synergistic chemotherapy and photodynamic therapy, ACS Applied Materials & Interfaces, 2020, 12: 24662-24674.
[5] Shen-Zhen Ren; Dan Zhu; Xiao-Hua Zhu; Bin Wang; Yu-Shun Yang; Wen-Xue Sun; Xiao-Ming Wang; Peng-Cheng Lv*; Zhong-Chang Wang*; Hai-Liang Zhu*, Nanoscale metal-organic frameworks coated by biodegradable organosilica for pH and redox dual responsive drug release and high-performance anticancer therapy, ACS Applied Materials & Interfaces, 2019, 11: 20678-20688.
[6] Shen-Zhen Ren; Zhong-Chang Wang*; Dan Zhu; Xiao-Hua Zhu; Fa-Qian Shen; Song-Yu Wu; Jin-Jin Chen; Chen Xu*; Hai-Liang Zhu*, Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy, European Journal of Medicinal Chemistry, 2018, 157: 909-924.
[7] Shen-Zhen Ren; Zhong-Chang Wang*; Xiao-Hua Zhu; Dan Zhu; Zhang Li; Fa-Qian Shen; Yong-Tao Duan; Han Cao; Jing Zhao*; Hai-Liang Zhu*, Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and chrysin for selective COX-2 inhibition, Bioorganic & Medicinal Chemistry, 2018, 26: 4264-4275.
[8] Juan Sun#; Shen-Zhen Ren#; Xiao-Yuan Lu; Jing-Jing Li; Fa-Qian Shen; Chen Xu*; Hai-Liang Zhu*; Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors, Bioorganic & Medicinal Chemistry, 2017, 25(9): 2593-2600.
发明专利:
[1]庞春丽、杨潇、安海龙、任深圳:多酚介导的多功能仿生金属-有机骨架混合结构及其制备与应用。公开号:CN114366722A。
[2]武松宇、任深圳、叶亚熙:一种酶抑制剂的荧光标记的合成。公开号:CN112707921A。
[3]任深圳、武松宇、叶亚熙:一类含阿魏酸-吡唑骨架的抗肿瘤化合物的设计与合成。公开号:CN112707864A。
[4]武松宇、叶亚熙、任深圳:一种COX-2酶抑制剂的荧光标记物的合成。公开号:CN112707913A。
[5]朱海亮、任深圳、朱丹、王忠长、徐琛:一类含NO供体的二茂铁-吡唑磺胺衍生物的设计、合成及其生物活性评价。公开号:CN110698519A。
[6]朱海亮、任深圳、朱晓华、王忠长、赵劲:一类含吡唑骨架的白杨素衍生物的设计、合成及其生物活性评价。公开号:CN110698464A。
五、联系人:任深圳, 联系方式:rensz@hebut.edu.cn